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Gene Expression Data
Assay Details
Assay
Reference: J:93603 Wine-Lee L, et al., Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development. 2004 Nov;131(21):5393-403
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3511818
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: clone 39.4D5
Assay notes: The antibody used in this assay recognizes two family members.
Results
Specimen 6G: embryonic day 10.5 (more )
Note: Double labeled: green - Isl1 and Isl2; red - Pax2 (assay MGI:3511813).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6G Expression is in the DI3 dorsal sensory interneurons.
Specimen 6H: embryonic day 10.5; Bmpr1atm1Bhr/Bmpr1atm2.1Bhr, Bmpr1btm1Kml/Bmpr1btm1Kml, Tg(Pou3f4-cre)32Cren/0 (more )
Note: Conditional mutant. Double labeled: green - Isl1 and Isl2; red - Pax2 (assay MGI:3511813).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6H Expression is in the DI3 dorsal sensory interneurons. In the mutant this population is increased and dorsally expanded; they are found almost adjacent to the roof plate.
Specimen 7E: embryonic day 11.5 (more )
Note: Double labeled: green - Isl1 and Isl2; red - Pax2 (assay MGI:3511813).
Structure Level Pattern Image Note
TS19: neural tube lateral wall Present Regionally restricted 7E Expression is in the DI3 dorsal sensory interneurons and ventral motoneurons.
Specimen 7F: embryonic day 11.5; Bmpr1atm1Bhr/Bmpr1atm2.1Bhr, Bmpr1btm1Kml/Bmpr1btm1Kml, Tg(Pou3f4-cre)32Cren/0 (more )
Note: Conditional mutant. Double labeled: green - Isl1 and Isl2; red - Pax2 (assay MGI:3511813).
Structure Level Pattern Image Note
TS19: neural tube lateral wall Present Regionally restricted 7F Expression in the ventral motoneurons is unaffected in the mutants; expression in the DI3 cells is shifted dorsally toward the roof plate but is otherwise unaffected.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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