Six1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:83432 Xu PX, et al., Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:2681332
Gene symbol:	Six1
Gene name:	sine oculis-related homeobox 1

Reporter:	lacZ
	Direct Detection
Assay notes:	The combination of the strain backgrounds for the double heterozygous animals is complex and can be found in the article and the references therein.

Results

1B ©

Specimen 1B: embryonic day 10.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Image	Note
TS18: metanephric mesenchyme	Present	1B
TS18: nephric duct	Absent	1B
TS18: ureteric bud	Absent	1B	Expression was absent in the ureteric bud epithelium.

1C ©

Specimen 1C: embryonic day 11.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS19: mesonephros mesenchyme	Present	Regionally restricted	1C	Expression was detected in the induced mesenchyme around the ureteric bud epithelium.

1D ©

Specimen 1D: embryonic day 17.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: cortical renal tubule	Present	Regionally restricted	1D	Expression was detected in the metanephric tubules.
TS25: integumental system muscle	Present	Regionally restricted	1D	Expression was detected in the muscles surrounding the ureter.

1E ©

1F ©

Specimen 1E, 1F: embryonic day 17.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: collecting duct	Present		1E , 1F	Expression was detected in the collecting tubules.

6A +/- ©

Specimen 6A left: embryonic day 17.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: integumental system muscle	Present	Regionally restricted	6A +/-	Expression was detected in the muscles surrounding the ureter and kidney.

6A +/-+/- ©

Specimen 6A right: embryonic day 17.5; Eya1^tm1Rilm/Eya1⁺, Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: integumental system muscle	Present	Regionally restricted	6A +/-+/-	Expression was detected in the muscles surrounding the ureter and kidney.

6C +/- ©

Specimen 6C left: embryonic day 17.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: integumental system muscle	Present	Regionally restricted	6C +/-	Expression was detected in the muscles surrounding the ureter and kidney.

6C +/-+/- ©

Specimen 6C right: embryonic day 17.5; Eya1^tm1Rilm/Eya1⁺, Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: integumental system muscle	Present	Regionally restricted	6C +/-+/-	Expression was detected in the muscles surrounding the ureter and kidney.

6D +/- ©

Specimen 6D left: embryonic day 17.5; Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: testis	Present		6D +/-
TS25: integumental system muscle	Present	Regionally restricted	6D +/-	Expression was detected in the muscles surrounding the ureter and kidney.

6D +/-+/- ©

Specimen 6D right: embryonic day 17.5; Eya1^tm1Rilm/Eya1⁺, Six1^tm1Mair/Six1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: testis	Present		6D +/-+/-
TS25: integumental system muscle	Present	Regionally restricted	6D +/-+/-	Expression was detected in the muscles surrounding the ureter and kidney.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24