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Gene Expression Data
Assay Details
Assay
Reference: J:71034 Boyl PP, et al., Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Development. 2001 Aug;128(15):2989-3000
Assay type: RNA in situ
MGI Accession ID: MGI:2150147
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Results
Specimen 3A wt: embryonic day 6.5 (more )
Structure Level Pattern Image Note
TS8: extraembryonic visceral endoderm Present 3A
TS8: epiblast Present 3A

Specimen 3B Otx2 +/-: embryonic day 6.5; Otx2tm1Pas/Otx2+ (more )
Structure Level Pattern Image Note
TS8: epiblast Present 3B Expression in this mutant is the same as in wild-type embryos.
TS8: extraembryonic visceral endoderm Present 3B Expression in this mutant is the same as in wild-type embryos.

Specimen 3C Otx2 l/l: embryonic day 6.5; Otx2tm1Pas/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS8: epiblast Present 3C Expression in this mutant is the same as in wild-type embryos.
TS8: extraembryonic visceral endoderm Present 3C Expression in this mutant is the same as in wild-type embryos.

Specimen 3D Otx2 l/-: embryonic day 6.5; Otx2tm2Asim/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS8: epiblast Present 3D Expression in this mutant is the same as in wild-type embryos.
TS8: extraembryonic visceral endoderm Present 3D Expression in this mutant is the same as in wild-type embryos.

Specimen 3E wt: embryonic day 7.75 (more )
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 3E Expression is in the axial mesendoderm.
TS11: neural ectoderm Present Regionally restricted 3E Expression is anterior.
TS11: extraembryonic visceral endoderm Present 3E

Specimen 3F Otx2 +/-: embryonic day 7.75; Otx2tm1Pas/Otx2+ (more )
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 3F Expression is in axial mesendoderm. Expression in this mutant is the same as in wild-type embryos.
TS11: neural ectoderm Present Regionally restricted 3F Expression is anterior. Expression in this mutant is the same as in wild-type embryos.
TS11: extraembryonic visceral endoderm Present 3F

Specimen 3G Otx2 l/l: embryonic day 7.75; Otx2tm1Pas/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 3G Expression is in the axial mesendoderm. Expression in this mutant is the same as in wild-type embryos.
TS11: neural ectoderm Present Regionally restricted 3G Expression is anterior. Expression in this mutant is the same as in wild-type embryos.
TS11: extraembryonic visceral endoderm Present 3G

Specimen 3H Otx2 l/-: embryonic day 7.75; Otx2tm2Asim/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 3H Expression is in the axial mesendoderm. Expression in this mutant is the same as in wild-type embryos.
TS11: neural ectoderm Present Regionally restricted 3H Expression is anterior. Expression in this mutant is the same as in wild-type embryos.
TS11: extraembryonic visceral endoderm Present 3H

Specimen 6A wt: embryonic day 6.5 (more )
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present 6A

Specimen 6B Otx2 l/-: embryonic day 6.5; Otx2tm1Pas/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present 6B Expression in the mutant is similar to that seen in wild type.

Specimen Not shown Otx2 l/l: embryonic day 6.5; Otx2tm2Asim/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present Expression in the mutant is similar to that seen in wild type.

Specimen 6G wt: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: neural ectoderm Present Regionally restricted 6G Expression is anterior.
TS11: mesendoderm Present Regionally restricted 6G Expression is in the axial mesendoderm.
TS11: extraembryonic visceral endoderm Present 6G

Specimen 6H Otx2 l/-: embryonic day 7.5; Otx2tm1Pas/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS11: neural ectoderm Present Regionally restricted 6H Expression is anterior. Expression in the mutant is similar to that seen in wild type.
TS11: mesendoderm Present Regionally restricted 6H Expression is in the axial mesendoderm. Expression in the mutant is similar to that seen in wild type.
TS11: extraembryonic visceral endoderm Present 6H Expression in the mutant is similar to that seen in wild type.

Specimen Not shown Otx2 l/l: embryonic day 7.5; Otx2tm2Asim/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS11: neural ectoderm Present Regionally restricted Expression is anterior. Expression in the mutant is similar to that seen in wild type.
TS11: mesendoderm Present Regionally restricted Expression is present in the axial mesendoderm. Expression in the mutant is similar to that seen in wild type.
TS11: extraembryonic visceral endoderm Present Expression in the mutant is similar to that seen in wild type.

Specimen 8A wt: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain Present 8A
TS17: midbrain Present 8A

Specimen 8B Otx2 l/l: embryonic day 10.5; Otx2tm2Asim/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 8B Expression is present in a smaller domain in the mutant than in wild type.

Specimen 8C Otx2 l/-: embryonic day 10.5; Otx2tm1Pas/Otx2tm2Asim (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 8C Expression is present in the rostral-most neuroectoderm.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory