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Gene Expression Data
Assay Details
Assay
Reference: J:67157 McCright B, et al., Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development. 2001 Feb;128(4):491-502
Assay type: RNA in situ
MGI Accession ID: MGI:2150116
Gene symbol: Notch2
Gene name: notch 2
Probe: Notch2 cDNA4
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: atrioventricular canal Absent
TS19: endocardial cushion Absent
TS19: heart atrium Absent
TS19: heart mesentery Absent
TS19: heart ventricle Absent
TS19: pericardium Absent
TS19: sinus venosus Absent
TS19: outflow tract Present
Specimen E11.5: embryonic day 11.5; Notch2tm1Grid/Notch2tm1Grid (more )
Structure Level Pattern Image Note
TS19: atrioventricular canal Absent
TS19: endocardial cushion Absent
TS19: heart atrium Absent
TS19: heart mesentery Absent
TS19: heart ventricle Absent
TS19: pericardium Absent
TS19: sinus venosus Absent
TS19: outflow tract Present
Specimen E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: atrioventricular canal Absent
TS22: atrioventricular endocardial cushion Absent
TS22: bulbar cushion Absent
TS22: endocardial cushion Absent
TS22: endocardial tissue Absent
TS22: heart atrium Absent
TS22: heart mesentery Absent
TS22: heart valve Absent
TS22: heart ventricle Absent
TS22: pericardium Absent
TS22: outflow tract Present
Specimen E14.5: embryonic day 14.5; Notch2tm1Grid/Notch2tm1Grid (more )
Structure Level Pattern Image Note
TS22: atrioventricular canal Absent
TS22: atrioventricular endocardial cushion Absent
TS22: bulbar cushion Absent
TS22: endocardial cushion Absent
TS22: endocardial tissue Absent
TS22: heart atrium Absent
TS22: heart mesentery Absent
TS22: heart valve Absent
TS22: heart ventricle Absent
TS22: pericardium Absent
TS22: outflow tract Strong
Specimen 3 A, B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 3A , 3B Expression in ureteric bud-derived collecting duct system and condensations and vesicular structures such as metanephric vesicles and comma and S-shape bodies. In maturing glomeruli, expression is at the periphery.
TS24: renal cortex Present Regionally restricted 3A , 3B Expression in ureteric bud-derived collecting duct system and condensations and vesicular structures such as metanephric vesicles and comma and S-shape bodies. In maturing glomeruli, expression is at the periphery.
Specimen 3 H: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: collecting duct Present Regionally restricted 3H Expression in ureteric bud-derived collecting duct system and condensations and vesicular structures such as metanephric vesicles and comma and S-shape bodies. In maturing glomeruli, expression is at the periphery.
TS26: glomerular tuft Present Regionally restricted 3H Expression in ureteric bud-derived collecting duct system and condensations and vesicular structures such as metanephric vesicles and comma and S-shape bodies. In maturing glomeruli, expression is at the periphery.
Specimen -/-: embryonic day 16.5; Notch2tm1Grid/Notch2tm1Grid (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted
TS24: renal cortex Present Regionally restricted
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory