Mycn RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:11859 Sawai S, et al., Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development. 1993 Apr;117(4):1445-55
Assay type:	RNA in situ
MGI Accession ID:	MGI:1928872
Gene symbol:	Mycn
Gene name:	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

Probe:	Nmyc1 probe4
Probe preparation:	Antisense

Results

4A/B ©

Specimen 4A/B: embryonic day 10.5 (more

)
Note: Fig. 4A is a phase-contrast image and 4B is a dark-field image.

Structure	Level	Image	Note
TS17: liver	Absent	4A/B	Authors report absence of expression on liver cells.
TS17: stomach epithelium	Strong	4A/B
TS17: stomach mesenchyme	Weak	4A/B

4C/D ©

Specimen 4C/D: embryonic day 12.0 (more

)
Note: Fig. 4C is a phase-contrast image and 4D is a dark-field image.

Structure	Level	Pattern	Image	Note
TS20: lung epithelium	Strong	Regionally restricted	4C/D	Expression was high on the bronchial epithelia.

Specimen Table 2: embryonic day 9.5 (more

)

Structure	Level	Pattern	Note
TS15: cardiac muscle tissue	Present
TS15: limb mesenchyme	Present
TS15: foregut	Present
TS15: lung mesenchyme	Present
TS15: neural tube	Present
TS15: spinal ganglion	Present
TS15: branchial arch mesenchyme	Present
TS15: visceral organ system	Present	Regionally restricted	Expression in the liver mesenchyme.
TS15: lens placode	Present	Regionally restricted	Expression in the neural retina and lens.
TS15: optic cup	Present	Regionally restricted	Expression in the neural retina and lens.

Specimen Table 2: embryonic day 10.5 (more

)

Structure	Level	Pattern	Note
TS17: cardiac muscle tissue	Present
TS17: lung mesenchyme	Present
TS17: neural tube	Present
TS17: spinal ganglion	Present
TS17: stomach mesenchyme	Present
TS17: branchial arch mesenchyme	Present
TS17: hepatic primordium parenchyma	Present	Regionally restricted	Expression in the liver mesenchyme,
TS17: limb mesenchyme	Present	Regionally restricted
TS17: lens pit	Present	Regionally restricted	Expression in the neural retina and lens.
TS17: optic cup	Present	Regionally restricted	Expression in the neural retina and lens.

Specimen Table 2: embryonic day 11.5 (more

)

Structure	Level	Pattern	Note
TS19: cardiac muscle tissue	Present
TS19: neural tube	Present	Regionally restricted	Expression in the dorsal region.
TS19: spinal ganglion	Present	Regionally restricted	Expression in the neurons.
TS19: lung	Present	Regionally restricted	Expression in the bronchial tubes.
TS19: limb	Weak
TS19: stomach epithelium	Present
TS19: stomach mesenchyme	Present
TS19: lens vesicle	Present		Expression in the neural retina and lens.
TS19: retina	Present		Expression in the neural retina and lens.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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