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Gene Expression Data
Assay Details
Assay
Reference: J:60095 Barrow JR, et al., Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development. 2000 Mar;127(5):933-44
Assay type: RNA in situ
MGI Accession ID: MGI:1353305
Gene symbol: Nrg1
Gene name: neuregulin 1
Probe: neuregulin probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4A: embryonic day 9.0-9.25; Hoxa2tm1Mrc/Hoxa2+ (more )
Structure Level Pattern Image Note
TS14: rhombomere 2 Strong 4A
TS14: rhombomere 4 Strong 4A
TS14: rhombomere 1 Weak 4A
TS14: rhombomere 3 Weak 4A
TS14: rhombomere 5 Weak 4A

Specimen 4B: embryonic day 9.0-9.25; Hoxa1tm2Mrc/Hoxa1+, Hoxa2tm1Mrc/Hoxa2tm1Mrc (more )
Structure Level Pattern Image Note
TS14: rhombomere 2 Strong 4B The mutant embryo has the same expression pattern as the control.
TS14: rhombomere 4 Strong 4B The mutant embryo has the same expression pattern as the control.
TS14: rhombomere 1 Weak 4B The mutant embryo has the same expression pattern as the control.
TS14: rhombomere 3 Weak 4B The mutant embryo has the same expression pattern as the control.
TS14: rhombomere 5 Weak 4B The mutant embryo has the same expression pattern as the control.

Specimen 4C: embryonic day 9.0-9.25; Hoxa1tm1Mrc/Hoxa1tm1Mrc (more )
Structure Level Pattern Image Note
TS14: rhombomere 5 Present 4C This is believed to be a mis-specification of rhombomere 4 at the level of rhombomere 5.
TS14: rhombomere 3 Absent 4C
TS14: rhombomere 4 Present Regionally restricted 4C There is an anterior region that does not express.

Specimen 4D: embryonic day 9.0-9.25; Hoxa1tm2Mrc/Hoxa1tm2Mrc, Hoxa2tm1Mrc/Hoxa2tm1Mrc (more )
Structure Level Pattern Image Note
TS14: rhombomere 3 Present Regionally restricted 4D
TS14: rhombomere 5 Present 4D This expression is interpreted as rhombomere 4 expression at the level of rhombomere 5.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory