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Gene Expression Data
Assay Details
Assay
Reference: J:41540 Rossel M, et al., Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development. 1999 Nov;126(22):5027-40
Assay type: RNA in situ
MGI Accession ID: MGI:1346700
Gene symbol: Hoxb2
Gene name: homeobox B2
Probe: Hoxb2 probe2
Probe preparation: RNA
Results
Specimen 5A: embryonic day 9.5; Hoxa1tm1Mrc/Hoxa1+, Hoxb1tm3Mrc/Hoxb1+ (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Strong 5A
TS15: rhombomere 4 Strong 5A
TS15: rhombomere 5 Strong 5A
TS15: migrating neural crest Strong Single cells 5A Hoxb2 is strongly expressed in the neural crest cells migrating from r4 and r6 into the 2nd and 3rd branchial arches.
Specimen 5B: embryonic day 9.5; Hoxa1tm1Mrc/Hoxa1tm1Mrc, Hoxb1tm3Mrc/Hoxb1tm3Mrc (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Present Spotted 5B Expression is patchy and discontinuous in this mutant.
TS15: migrating neural crest Present Single cells 5B The broad stripe of Hoxb2-labeled neural crest normally emanating from r4 and migrating ventrally to the 2nd branchial arch is not seen. Instead, at this position a small population of labeled neural crest (presumably from r6) is migrating caudally.
Specimen aaBb: embryonic day 9.5; Hoxa1tm1Mrc/Hoxa1tm1Mrc, Hoxb1tm3Mrc/Hoxb1+ (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Present Spotted Expression is patchy and discontinuous in this mutant.
TS15: migrating neural crest Present Single cells The broad stripe of Hoxb2-labeled neural crest normally emanating from r4 and migrating ventrally to the 2nd branchial arch is not seen. Instead, at this position a small population of labeled neural crest (presumably from r6) is migrating caudally.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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