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Gene Expression Data
Assay Details
Assay
Reference: J:49251 Matise MP, et al., Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 1998 Aug;125(15):2759-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:1342596
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: anti-C-Isl-1 protein (K5)
Detection system: Secondary antibody
Results
Specimen 2.F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 2F Expression is seen in two lateral motor column clusters.
Specimen 2.G: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 2G Expression is seen in motoneurons in the region normally occupied by the floor plate.
Specimen 3.A: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 3A Some expressing cells also express Nkx2-2.
Specimen 3.B: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 3B Most expressing cells also express Nkx2-2.
Specimen 8.A: embryonic day 12.5; Gli1tm1Alj/Gli1tm1Alj (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 8A Expression is similar to that seen in the wild-type.
Specimen 8.C: embryonic day 12.5; Gli2tm1Alj/Gli2tm1Alj, Gli3Xt-J/Gli3+ (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 8C In contrast to wild-type, in the double mutant expression was seen in the ventral midline.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory