Fgf8 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:56564 De Arcangelis A, et al., Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development. 1999 Sep;126(17):3957-68
Assay type:	RNA in situ
MGI Accession ID:	MGI:1342458
Gene symbol:	Fgf8
Gene name:	fibroblast growth factor 8

Probe:	Fgf8 cDNA13
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

7a ©

Specimen 7a: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: handplate apical ectodermal ridge	Present		7a

7b ©

Specimen 7b: embryonic day 11.5; Itga3^tm1Jak/Itga3^tm1Jak, Itga6^tm1Egl/Itga6^tm1Egl (more

)

Structure	Level	Pattern	Image	Note
TS19: handplate apical ectodermal ridge	Present	Regionally restricted	7b	In mutants, the signal is less intense than in wild-type. The signal always presents alterations in that the domain of expression is broader, patchy and irregular. In some limbs the signal is discontiuous.

Specimen not shown: embryonic day 10.5; Itga3^tm1Jak/Itga3^tm1Jak, Itga6^tm1Egl/Itga6^tm1Egl (more

)

Structure	Level	Pattern	Image	Note
TS17: apical ectodermal ridge	Present

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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