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Gene Expression Data
Assay Details
Assay
Reference: J:45779 Jernvall J, et al., The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development. 1998 Jan;125(2):161-9
Assay type: RNA in situ
MGI Accession ID: MGI:1332281
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe50
Probe preparation: labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1 left: embryonic day 13.0 (more )
Note: Bud stage; initiation.
Structure Level Pattern Image Note
TS21: lower jaw molar mesenchyme Present Regionally restricted 1_Bmp-4 left Expression seen in the dental mesenchyme at the bud stage.

Specimen 1 right: embryonic day 14.0 (more )
Note: Cap stage; fully formed.
Structure Level Pattern Image Note
TS22: enamel knot Present Regionally restricted 1_Bmp-4 right Expression seen in the distal part of the enamel knot at the cap stage.
TS22: lower jaw molar enamel organ Present Regionally restricted 1_Bmp-4 right Expression seen in the distal part of the enamel knot at the cap stage.
TS22: lower jaw molar mesenchyme Present Widespread 1_Bmp-4 right Expression seen along the whole tooth germ.

Specimen 3 top: embryonic day 14.0 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: enamel knot Present Regionally restricted 3_Bmp-4 top Expression seen in the distal part of the enamel knot at the cap stage.
TS22: lower jaw molar enamel organ Present Regionally restricted 3_Bmp-4 top Expression seen in the distal part of the enamel knot at the cap stage.

Specimen 3 bottom: embryonic day 14.5-15.0 (more )
Note: Late cap stage.
Structure Level Pattern Image Note
TS22: lower jaw molar dental papilla Present Regionally restricted 3_Bmp-4 bottom Expression seen in the dental papilla mesenchyme and in the surrounding mesenchyme along the whole tooth germ in its buccal side.
TS22: lower jaw molar mesenchyme Present Regionally restricted 3_Bmp-4 bottom Expression seen in the dental papilla mesenchyme and in the surrounding mesenchyme along the whole tooth germ in its buccal side.
TS22: enamel knot Strong Regionally restricted 3_Bmp-4 bottom Abundant expression seen in the distal part of the remaining enamel knot.
TS22: lower jaw molar enamel organ Strong Regionally restricted 3_Bmp-4 bottom Abundant expression seen in the distal part of the remaining enamel knot.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory