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Gene Expression Data
Assay Details
Assay
Reference: J:44237 Goh KL, et al., Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
Assay type: RNA in situ
MGI Accession ID: MGI:1331631
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh probe5
Assay notes: Fixative for these specimens is 4%paraformaldehyde/ 0.1% gleteraldehyde.
Results
Specimen 7C,D -/-: embryonic day 8.75; Itga5tm1Hyn/Itga5tm1Hyn (more )
Structure Level Pattern Image Note
TS14: notochord Present Regionally restricted 7C -/- , 7D -/- There were abnormal discontinuities of expression in the mutant notochord compared to wild type.
TS14: gut Present 7D -/- , 7C -/- Expression was detected as in wild type.
TS14: neural tube floor plate Present 7D -/- , 7C -/- Expression was detected as in wild type.
Specimen 7C,D wt: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: notochord Present 7D wt , 7C wt
TS14: gut Present 7D wt , 7C wt
TS14: neural tube floor plate Present 7D wt , 7C wt
Specimen 7E: embryonic day 8.75; Itga5tm1Hyn/Itga5tm1Hyn (more )
Structure Level Pattern Image Note
TS14: notochord Present Regionally restricted 7E There were abnormal discontinuities of expression in the mutant notochord compared to wild type.
Specimen 7F: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: notochord Present 7F
Specimen 8D: embryonic day 8.75; Itga5tm1Hyn/Itga5tm1Hyn (more )
Note: Section of the embryo shown in Fig. 7C.
Structure Level Pattern Image Note
TS14: notochord Present 8D Expression was detected as in wild type.
TS14: gut Strong 8D
TS14: neural tube floor plate Strong 8D
Specimen 8E: embryonic day 8.75; Itga5tm1Hyn/Itga5tm1Hyn (more )
Note: Section of the embryo shown in Fig. 7C. This section is serial to that in Fig. 8D.
Structure Level Pattern Image Note
TS14: notochord Absent 8E The notochord structure was absent.
TS14: gut Present 8E
TS14: neural tube floor plate Present 8E
Specimen 8F: embryonic day 8.75; Itga5tm1Hyn/Itga5tm1Hyn (more )
Note: Section of the embryo shown in Fig. 7C. This section is more caudal to that in Fig. 8D.
Structure Level Pattern Image Note
TS14: notochord Absent 8F The notochord structure was present, but staining was not detected in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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