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Gene Expression Data
Assay Details
Assay
Reference: J:49252 Hardcastle Z, et al., The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development. 1998 Aug;125(15):2803-11
Assay type: RNA in situ
MGI Accession ID: MGI:1320898
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh cDNA5
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Present Regionally restricted 1B Expression seen in the epithelial thickenings of all the tooth germs.
TS19: maxillary process Present Regionally restricted 1B Expression seen in the epithelial thickenings of all the tooth germs.

Specimen 1H: embryonic day 12.5 (more )
Note: Early tooth bud stage.
Structure Level Pattern Image Note
TS20: mandibular process Strong Regionally restricted 1H Expression intensified at the early bud stage in both the maxillary and mandibular incisors.
TS20: maxillary process Strong Regionally restricted 1H Expression intensified at the early bud stage in both the maxillary and mandibular incisors.

Specimen 1N: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw tooth epithelium Present Regionally restricted 1N Expression restricted to cells that will form the enamel knot.
TS21: upper jaw tooth epithelium Present Regionally restricted 1N Expression restricted to cells that will form the enamel knot.

Specimen 1T: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: lower jaw tooth enamel organ Present Regionally restricted 1T , 1Z Expression clearly marks the enamel knot.
TS22: upper jaw tooth enamel organ Present Regionally restricted 1T , 1Z Expression clearly marks the enamel knot.
TS22: enamel knot Present 1Z , 1T

Specimen not shown: embryonic day 14.5; Gli2tm1Alj/Gli2tm1Alj (more )
Structure Level Pattern Image Note
TS22: upper jaw incisor Present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory