Mtorem1Vic
Endonuclease-mediated Allele Detail
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| Symbol: |
Mtorem1Vic |
| Name: |
mechanistic target of rapamycin kinase; endonuclease-mediated mutation 1, Gabriel Victora |
| MGI ID: |
MGI:6295460 |
| Synonyms: |
MtorF2108L |
| Gene: |
Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
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| Alliance: |
Mtorem1Vic page
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| Allele Type: |
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Endonuclease-mediated (Not Applicable) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: CRISPR-targeting of exon 45 engineered nucleotide substitutions to produce a G to C silent mutation creating an AfIII reaction enzyme site, C to A resulting in the amino acid substitution of leucine for phenylalanine at position 2108 (F2108L) and several silent mutations to prevent Cas9 recutting. The amino acid substitution produces rapamycin resistance.
(J:259205)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mtor Mutation: |
80 strains or lines available
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| Original: |
J:259205 Ersching J, et al., Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity. 2017 Jun 20;46(6):1045-1058.e6 |
| All: |
1 reference(s) |
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Analysis Tools
