Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Bmx-cre/ERT2)1Rha
Name:	transgene insertion 1, Ralf H Adams
MGI ID:	MGI:5513853
Synonyms:	Bmx(PAC)-CreERT2
Transgene:	Tg(Bmx-cre/ERT2)1Rha  Location: unknown
Alliance:	Tg(Bmx-cre/ERT2)1Rha page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Bmx-cre/ERT2)1Rha expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Bmx (MGI:1101778)   Mutation details: cDNA encoding cre recombinase fused to the mutated human estrogen receptor ligand-binding domain (ERT2) and followed by a polyadenylation signal and an Frt-flanked neo cassette was inserted into the start codon of the mouse Bmx gene located in the P1 artificial chromosome (PAC; RPCI21) using recombineering methods. Flp-mediated excision in bacteria removed the neo marker. The validated construct was injected into fertilized oocytes to generate founders (details not available). Founders were bred to reporter mice to assess recombination efficiency and specificity; mice display inducible artery-specific cre activity. (J:198633)

Activity:	Tissue activity of this recombinase allele
Driver:	Bmx (mouse) Summary of all recombinase alleles driven by Bmx. Alliance mouse Bmx gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:198633 Ehling M, et al., Notch controls retinal blood vessel maturation and quiescence. Development. 2013 Jul;140(14):3051-61
All:	21 reference(s)