Phenotypes Associated with This Genotype

Genotype
MGI:8434074

• Allelic Composition: Lss^{tm1c(KOMP)Wtsi}/Lss^{tm1c(KOMP)Wtsi}; Tg(Pax6-GFP/cre)1Rilm/0
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina ganglion cell number ( J:286778 )

abnormal lens morphology ( J:286778 )

• lens swelling, lens degeneration, and lens liquefaction

• (S)-2,3-epoxysqualene, lanosterol, squalene, and cholesterol are not detected in the lenses

cataract ( J:286778 )

• small cloudy lenses

microphthalmia ( J:286778 )

thin retina ganglion layer ( J:286778 )

thin retina inner nuclear layer ( J:286778 )

nervous system

decreased retina ganglion cell number ( J:286778 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 44		DOID:0110267	OMIM:616509	J:286778