Phenotypes Associated with This Genotype

Genotype
MGI:8434068

• Allelic Composition: Lss^{tm1c(KOMP)Wtsi}/Lss^{tm1c(KOMP)Wtsi}; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * CD-1 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal outer ear skin morphology ( J:286778 )

• surfaces of the ears or tails of tamoxifen-treated mice are reddish and rough

sebaceous gland hyperplasia ( J:286778 )

abnormal sebaceous gland physiology ( J:286778 )

• ratios of (S)-2,3-epoxysqualene to lanosterol are higher in the sebum of tamoxifen-treated mice

alopecia ( J:286778 )

• 4 weeks after tamoxifen-treatment mice exhibit alopecia from the head to the back that is spontaneously and partially reversed 7 weeks after tamoxifen treatment

• epilation occurs over 3 weeks after intraperitoneal injections of tamoxifen and in the following 1 to 2 weeks, the hair loss area peaks

• fur gradually regrows, but is not completely restored and remains sparse

• mice administered 4-hydroxytamoxifen topically on the skin show transient epilation in treated areas

abnormal hair follicle morphology ( J:286778 )

• tamoxifen-treated mice exhibit hypoplastic hair follicles and thin root sheaths

abnormal epidermal layer morphology ( J:286778 )

• epidermis exhibits liquefaction degeneration

hyperkeratosis ( J:286778 )

parakeratosis ( J:286778 )

acanthosis ( J:286778 )

• epidermis shows severe acanthosis

epidermal hyperplasia ( J:286778 )

craniofacial

abnormal outer ear skin morphology ( J:286778 )

• surfaces of the ears or tails of tamoxifen-treated mice are reddish and rough

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:286778 )

abnormal sebaceous gland physiology ( J:286778 )

• ratios of (S)-2,3-epoxysqualene to lanosterol are higher in the sebum of tamoxifen-treated mice

growth/size/body

abnormal outer ear skin morphology ( J:286778 )

• surfaces of the ears or tails of tamoxifen-treated mice are reddish and rough

hearing/vestibular/ear

abnormal outer ear skin morphology ( J:286778 )

• surfaces of the ears or tails of tamoxifen-treated mice are reddish and rough

limbs/digits/tail

abnormal tail morphology ( J:286778 )

• surface of the tail of tamoxifen-treated mice is reddish and rough

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypotrichosis 14		DOID:0080582	OMIM:618275	J:286778