Analysis Tools
cellular
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• separation of inner membranes in optical nerve axons
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• loss of cristae in optical nerve axons
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• greater quantity of spherical and less variable mitochondria in optic nerve at age 360 days
• vacuolation in optical nerve axons
• disrupted mitochondria in retinal ganglion cell soma
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• increase in copy number in retinal tissues
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• accumulation of mitophagosomes in retinal ganglion cell soma
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growth/size/body
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• at age 180 days
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nervous system
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• greater quantity of spherical and less variable mitochondria in optic nerve at age 360 days
• vacuolation in optical nerve axons
• disrupted mitochondria in retinal ganglion cell soma
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• increase in copy number in retinal tissues
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• at age 180 days, continuing decline up to age 420 days
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• at ages 50 and 360 days
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• reduced number of myelinated axons in optic nerve at ages 50 and 360 days
• loose myelin sheath around axons in optic nerve at ages 50 and 360 days
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skeleton
vision/eye
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• at age 180 days, continuing decline up to age 420 days
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• at ages 50 and 360 days
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• at age 90 days
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• lower amplitude between peak positive waves (P1) and lowest negative waves (N2) in pattern ERG response at age 180 days, continuing decline up to age 630 days
• lower amplitude of photopic negative response at age 180 days
• normal a- and b-wave amplitudes in photopic ERG response at age 360 days
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• lower amplitude between peak positive waves (P1) and lowest negative waves (N2) in pattern ERG response at age 180 days, continuing decline up to age 630 days
• lower amplitude of scotopic negative response at age 180 days
• normal a- and b-wave amplitudes in scotopic ERG response at age 360 days
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| optic atrophy 1 | DOID:0111441 |
OMIM:165500 |
J:381209 | |
