Phenotypes Associated with This Genotype

Genotype
MGI:8286545

• Allelic Composition: Cabin1^em2Dcfaj/Cabin1^em2Dcfaj
• Genetic Background: C57BL/6J-Cabin1^em2Dcfaj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased spleen germinal center number ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

decreased spleen germinal center size ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

homeostasis/metabolism

increased circulating CCL2 level ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

increased circulating chemokine level ( J:378928 )

• increased CXCL13 and other chemokine and cytokine levels after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong or ovalbumin (OVA-lipid nanoparticles

increased circulating interleukin-6 level ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

immune system

immune system phenotype ( J:378928 )

N • normal baseline frequency of B, T and regulatory T cells, and other immune cell populations

decreased spleen germinal center number ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

decreased spleen germinal center size ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

increased circulating CCL2 level ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

increased circulating chemokine level ( J:378928 )

• increased CXCL13 and other chemokine and cytokine levels after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong or ovalbumin (OVA-lipid nanoparticles

increased circulating interleukin-6 level ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

cytokine storm ( J:378928 )

• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )

• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

mortality/aging

mortality/aging ( J:378928 )

N • no spontaneous mortality during 1st year

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )

• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multicentric Castleman disease		DOID:0111152		J:378928