Analysis Tools
muscle
 N |
• 12-week-old mice show normal muscle histology, normal muscle function, and exercise-induced damage
|
|
|
• 52-week-old mice show a decrease in contractile force at 75, 100, and 125 Hz after exercise
|
|
|
• 52-week-old, but not 12-week-old, exercised mice show reduced forelimb grip strength and contractile force indicating a fatigued phenotype
|
cardiovascular system
|
N |
• mice exhibit normal heart rate throughout 12 to 52 weeks of age, with normal ejection fraction and fractional shortening
|
|
|
• a small, but significant, increase in posterior wall thickness during diastole is seen at 12 weeks of age and a decrease in end diastolic diameter is seen at 28 weeks of age
• however, mice show normal echocardiography, with similar posterior wall thickness during systole, systolic volume, diastolic volume and end systolic diameter, throughout 12-52 weeks of age
|
homeostasis/metabolism
|
|
• forelimb grip strength after exercise is lower at 52 weeks of age but not at 12 weeks of age
• 52-week-old mice show a decrease in contractile force at 75, 100, and 125 Hz after exercise
• however, performances in open-field parameters are similar to wild-type mice pre- and post-exercise
|
behavior/neurological
|
|
• forelimb grip strength after exercise is lower at 52 weeks of age but not at 12 weeks of age
|
growth/size/body
|
N |
• 12-week-old mice show normal weight
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Becker muscular dystrophy | DOID:9883 |
OMIM:300376 |
J:376007 | |
