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Phenotypes Associated with This Genotype
Genotype
MGI:8249177
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Gt(ROSA)26Sortm1(Cacna1c*)Red/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Gt(ROSA)26Sortm1(Cacna1c*)Red mutation (0 available); any Gt(ROSA)26Sor mutation (1034 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
prolonged QT interval ( J:372210 )
• mice show prolongation of the QT interval at 4 days after tamoxifen administration
• mice treated with dextromethorphan and low dose of quinidine show shortening of the prolonged QT interval

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Timothy syndrome DOID:0060173 OMIM:601005
 J:372210

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory