integument
• mice start to lose nails by 12 weeks of age
|
• 12-week-old back skin shows possible minor disruption of anchoring fibrils within the basement layer
• skin shows a slightly thicker collagen VII layer
|
blistering
(
J:342863
)
• at P1, mice exhibit blisters on the paws and around the mouth, which disappear by P7
• blisters re-appear around the digits from approximately 5 to 10 weeks of age
• 12-week-old skin shows presence of microscopic blisters at the dermal-epidermal junction
• mice show a greater penetrance of blisters than Col7a1em3Kepa and Col7a1em5Kepa mice with most mice affected by 12 weeks of age
|
growth/size/body
N |
• mice exhibit normal weight gain during development
|
mortality/aging
N |
• no signs of increased mortality even up to 6 months of age are seen
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autosomal dominant dystrophic epidermolysis bullosa | DOID:0080224 |
OMIM:131750 |
J:342863 |