Analysis Tools
craniofacial
malocclusion
(
J:348336
)
|
• approximately 80% of mice develop malocclusion due to misaligned incisors
• however, tooth number and other facial features are normal
|
|
• temporomandibular joint condyles have reduced subchondral bone volume/tissue volume
|
endocrine/exocrine glands
| N |
• pancreatic cysts and ascites are uncommon
|
|
• livers appear to form major branches of the biliary system with diminished density of secondary branches
|
|
• newborn livers have an increased number of biliary cells but are macroscopically normal
|
|
• mice commonly exhibit bile duct dilatation
|
growth/size/body
malocclusion
(
J:348336
)
|
• approximately 80% of mice develop malocclusion due to misaligned incisors
• however, tooth number and other facial features are normal
|
|
• temporomandibular joint condyles have reduced subchondral bone volume/tissue volume
|
liver cyst
(
J:348336
)
|
• macroscopic liver cysts are present by 4 weeks of age and liver disease worsens with age
|
 |
• females have slightly larger kidneys
|
immune system
|
• mice commonly exhibit hypersplenism
|
liver/biliary system
|
• livers appear to form major branches of the biliary system with diminished density of secondary branches
|
|
• newborn livers have an increased number of biliary cells but are macroscopically normal
|
|
• mice commonly exhibit bile duct dilatation
|
liver cyst
(
J:348336
)
|
• macroscopic liver cysts are present by 4 weeks of age and liver disease worsens with age
|
renal/urinary system
| N |
• mice exhibit normal kidney tubules and glomeruli, with no evidence of dilatation or cyst formation in collecting ducts at various ages from birth to 15 months, with normal tubular diameter and cell number in tubular cross sections
|
|
|
• females have slightly larger kidneys
|
reproductive system
|
• small litter sizes are seen when using male homozygotes for breeding
• homozygous sperm fertilize eggs at a lower in vitro fertilization rate than controls
|
skeleton
malocclusion
(
J:348336
)
|
• approximately 80% of mice develop malocclusion due to misaligned incisors
• however, tooth number and other facial features are normal
|
|
• temporomandibular joint condyles have reduced subchondral bone volume/tissue volume
|
vision/eye
|
• all mice develop corneal opacities in one or both eyes detectable within the first 3-4 weeks of life and progressively worsens with age, invariably bilateral and sometimes results in corneal ulceration
|
cornea ulcer
(
J:348336
)
|
• seen sometimes
|
|
• corneal opacities are often accompanied by changes in eye globe size
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | autosomal recessive polycystic kidney disease | DOID:0110861 | J:348336 | |
