Phenotypes Associated with This Genotype

Genotype
MGI:8215115

• Allelic Composition: Tg(Eno2-Atxn7)#Cheo/0
• Genetic Background: C57BL/6-Tg(Eno2-Atxn7)#Cheo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:368250 )

♂N • mice show no differences in the percentage of preference for object in the novel object recognition task indicating that attention and/or learning and memory are unimpaired and no differences in the percentage of entries and the time spent in the open arms in the elevated plus-maze, falling frequency in the rotarod test, or in the percentage of spontaneous alternation in the Y-maze test

abnormal impulsive behavior control ( J:368250 )

♂ • in the delay discounting task, mice have decreased preference for the large reinforcer and increased number of non-reinforced responses indicating that mice are impulsive

♂ • mice treated with the ADHD drug atomoxetine show increased percentage of choice for the large reinforcer, ameliorating the impulsive behavior

hyperactivity ( J:368250 )

♂ • mice are hyperactive, showing increased distance moved and movement duration in the open-field test and mice have higher locomotor activity particularly on days 3, 5, and 7

♂ • mice treated with the ADHD drug atomoxetine show decreased locomotor activity, ameliorating the hyperactive behavior

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:368250