Phenotypes Associated with This Genotype

Genotype
MGI:8164245

ht1

• Allelic Composition: Trap1^em1Iimcb/Trap1⁺
• Genetic Background: B6.CBA-Trap1^em1Iimcb/Tar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal social/conspecific interaction behavior ( J:361875 )

♂ • analysis of in-cohort sociability, which measures how much time each pair of animals living in the same cage spends together shows that males, but not females, have deficits in social interaction, spending less time with other familiar mice

cellular

abnormal neuron mitochondrial morphology ( J:361875 )

♂ • density of presynaptic mitochondria is lower in the CA1 hippocampus of males

nervous system

abnormal neuron mitochondrial morphology ( J:361875 )

♂ • density of presynaptic mitochondria is lower in the CA1 hippocampus of males

abnormal synaptic bouton morphology ( J:361875 )

♂ • density of presynaptic mitochondria is lower in the CA1 hippocampus of males

abnormal dendritic spine morphology ( J:361875 )

♀ • females exhibit increased spine density, length, head width, and area in the medial prefrontal cortex

increased dendritic spine density ( J:361875 )

• males and females exhibit increased spine density in the medial prefrontal cortex

increased dendritic spine length ( J:361875 )

♀ • females exhibit increased spine length

abnormal excitatory postsynaptic potential ( J:361875 )

♀ • females exhibit reduced NMDAR-mediated synaptic transmission