Phenotypes Associated with This Genotype

Genotype
MGI:7720088

• Allelic Composition: Anln^em1(IMPC)Bay/Anln^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Anln^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Anln^em1(IMPC)Bay/Anln^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show developmental delay and poorly organized epithelia.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present at E7.5 (11% versus expected 25%, n=27); no homozygous embryos are recovered at E9.5

embryo

abnormal embryo development ( J:279207 )

• embryos show poorly organized epithelia at E7.5

• PL-1 (placental lactogen 1) signal indicates that the majority of cells recovered are trophoblast derivatives

embryonic growth retardation ( J:279207 )

• embryos show a developmental delay at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos show a developmental delay at E7.5