Phenotypes Associated with This Genotype

Genotype
MGI:7608058

• Allelic Composition: Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:345459 )

• male, and more so, female mice show reduced survival

behavior/neurological

abnormal habituation to a new environment ( J:345459 )

• 2-month-old mice present with slower habituation in the open field test, before development of memory deficits

hyperactivity ( J:345459 )

• 2-month-old mice present with in the open field test, before development of memory deficits

homeostasis/metabolism

amyloid beta deposits ( J:345459 )

• amyloid beta formation and plaque

nervous system

amyloid beta deposits ( J:345459 )

• amyloid beta formation and plaque

abnormal brain wave pattern ( J:345459 )

• hippocampal EEG recordings show increased spontaneous discharges and spike trains compared to controls

• spectral power analysis shows increased high frequency power compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:345459