Analysis Tools
mortality/aging
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• some pups die before 4 weeks of age due to hydrocephalus
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craniofacial
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• in mice with hydrocephaly
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nervous system
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• ependymal cilia show disruption of exoneme structures
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• sparse ependymal cilia in the ependymal epithelium
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hydrocephaly
(
J:338031
)
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• some pups die due to hydrocephalus
• hydrocephalus is characterized by enlarged dome-shaped skulls and enlargement of the brain ventricles
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• in mice with hydrocephaly
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reproductive system
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• flagella of remaining immotile spermatozoa show loss of the outer dense fibers that are associated with the missing peripheral doublet microtubules 4-7
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• the few remaining immotile spermatozoa in the cauda epididymis exhibit axoneme malformations; flagella exhibit missing peripheral doublet microtubules 4-7 with a concomitant loss of the associated outer dense fibers
• analysis of flagella formation during early stage of spermiogenesis indicates that microtubule-based axoneme structure formation is either blocked or seriously defective in round spermatids
• the formation rate of flagellar axonemes is lower in spermatids; axoneme structures are rarely seen in spermatids and the mitochondria exhibit a dispersed cytoplasmic distribution; the rare axoneme structures that are seem exhibit severe deformation of the 9+2 axoneme
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• spermatozoa are malformed with short and coiled flagella
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• spermatozoa are malformed with short and coiled flagella
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• sperm count in cauda epididymis is decreased, with only a few spermatozoa detected
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• total motility of sperm is decreased
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• males are completely infertile, with no pups born from males during a 2-month fertility test
• infertility of males is recovered by intracytoplasmic sperm injection (ICSI) and healthy offspring can be obtained using spermatozoa from mutant mice, however the rates of two-cell embryos and blastocyts are reduced upon ICSI treatment
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skeleton
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• in mice with hydrocephaly
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cellular
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• ependymal cilia show disruption of exoneme structures
|
|
• sparse ependymal cilia in the ependymal epithelium
|
|
|
• flagella of remaining immotile spermatozoa show loss of the outer dense fibers that are associated with the missing peripheral doublet microtubules 4-7
|
|
|
• the few remaining immotile spermatozoa in the cauda epididymis exhibit axoneme malformations; flagella exhibit missing peripheral doublet microtubules 4-7 with a concomitant loss of the associated outer dense fibers
• analysis of flagella formation during early stage of spermiogenesis indicates that microtubule-based axoneme structure formation is either blocked or seriously defective in round spermatids
• the formation rate of flagellar axonemes is lower in spermatids; axoneme structures are rarely seen in spermatids and the mitochondria exhibit a dispersed cytoplasmic distribution; the rare axoneme structures that are seem exhibit severe deformation of the 9+2 axoneme
|
|
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• spermatozoa are malformed with short and coiled flagella
|
|
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• spermatozoa are malformed with short and coiled flagella
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|
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• sperm count in cauda epididymis is decreased, with only a few spermatozoa detected
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|
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• total motility of sperm is decreased
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| oligoasthenoteratozoospermia | DOID:0070311 | J:338031 | ||
