Phenotypes Associated with This Genotype

Genotype
MGI:7491994

cx5

• Allelic Composition: Chd7^Whi/Chd7⁺; Fgfr1^Hspy/Fgfr1⁺
• Genetic Background: C3HeB/FeJ-Chd7^Whi Fgfr1^Hspy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:161880 )

• no mice were recovered at weaning (0/55)

perinatal lethality, complete penetrance ( J:161880 )

• 2 mice were recovered at P0 (1 dead), suggesting perinatal or early postnatal lethality

growth/size/body

cleft palate ( J:161880 )

• at E16.5, mice showed cleft palate with variable penetrance

choanal atresia ( J:161880 )

• at E16.5, mice showed choanal atresia with variable penetrance

craniofacial

cleft palate ( J:161880 )

• at E16.5, mice showed cleft palate with variable penetrance

choanal atresia ( J:161880 )

• at E16.5, mice showed choanal atresia with variable penetrance

cardiovascular system

abnormal heart morphology ( J:161880 )

• at E16.5, mice showed a heart defect with variable penetrance

digestive/alimentary system

cleft palate ( J:161880 )

• at E16.5, mice showed cleft palate with variable penetrance

respiratory system

choanal atresia ( J:161880 )

• at E16.5, mice showed choanal atresia with variable penetrance

nervous system

nervous system phenotype ( J:161880 )

N • mice showed a normal distribution of the GnRH1 neurons at E16.5

N • mice do NOT display olfactory bulb defects

reproductive system

reproductive system phenotype ( J:161880 )

N • mice do NOT display hypogonadotropic hypogonadism