Phenotypes Associated with This Genotype

Genotype
MGI:7437708

• Allelic Composition: Cwh43^em1Mdj/Cwh43^em2Mdj
• Genetic Background: C57BL/6-Cwh43^em1Mdj/Cwh43^em2Mdj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:310176 )

• 7-month-old mice show decreased balance times on the rotarod

abnormal gait ( J:310176 )

• gait analysis shows increased rear leg sway at 7 months of age

nervous system

hydrocephaly ( J:310176 )

• mice appear normal at birth but develop hydrocephalus during middle age

abnormal brain ependyma morphology ( J:310176 )

• the number of microvilli on the ependymal surface is decreased at 6 months of age

decreased brain ependyma motile cilium number ( J:310176 )

• the brain ventricular surface shows an approximate 25% decrease in the number of ependymal cilia at 6 months of age

• however, obvious differences in cilia length are not seen

dilated brain ventricle ( J:310176 )

• ventricular volume is increased by about 20.8% in 6-month-old mice

• however, brains are grossly normal and the cerebral aqueduct is patent

cellular

decreased brain ependyma motile cilium number ( J:310176 )

• the brain ventricular surface shows an approximate 25% decrease in the number of ependymal cilia at 6 months of age

• however, obvious differences in cilia length are not seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
normal pressure hydrocephalus		DOID:1572	OMIM:236690	J:310176