Phenotypes Associated with This Genotype

Genotype
MGI:7408193

• Allelic Composition: Ts(17¹⁶)66Yah/0
• Genetic Background: involves: C3H/HeSnJ * C57BL/6JEiJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:331897 )

N • mice exhibit normal behavior in an open field, distance traveled in the light and dark phases, spontaneous alternations in a Y-maze, and in a fear conditioning test

impaired spatial learning ( J:331897 )

• mice take longer mice to reach the platform in a Morris water maze than wild-type

• not as severe as in Ts(17¹⁶)65Dn mice

abnormal response to novel object ( J:331897 )

• mice spend more time exploring a novel object compared with wild-type mice

abnormal nest building behavior ( J:331897 )

• impaired nest building behavior

cellular

oligozoospermia ( J:331897 )

asthenozoospermia ( J:331897 )

nervous system

abnormal brain morphology ( J:331897 )

• not as severe as in Ts(17¹⁶)65Dn mice

reproductive system

oligozoospermia ( J:331897 )

asthenozoospermia ( J:331897 )

reduced male fertility ( J:331897 )

• 31 fertile males out of 49 tested

• not as severe as in Ts(17¹⁶)65Dn males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:331897