Phenotypes Associated with This Genotype

Genotype
MGI:7336151

• Allelic Composition: Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: WSB.Cg-Tg(APPswe,PSEN1dE9)85Dbo/How

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

impaired blood-brain barrier function ( J:276728 )

• Background Sensitivity: Fibrin was detected outside the microvessels in brains sections of hemizygotes on the WSB congenic background but not on the C57BL/6J congenic background or either wildtype control

homeostasis/metabolism

cerebral amyloid angiopathy ( J:276728 )

• Background Sensitivity: when congenial on CAST/EiJ or WSB/EiJ this Tg causes increased thioflavine S positive (ThioS+) vascular amyloid deposits, indicative of cerebral amyloid angiopathy, but this is not found in congenics on the C57BL/6J or PWK/PhJ host backgrounds

nervous system

impaired blood-brain barrier function ( J:276728 )

• Background Sensitivity: Fibrin was detected outside the microvessels in brains sections of hemizygotes on the WSB congenic background but not on the C57BL/6J congenic background or either wildtype control

cerebral amyloid angiopathy ( J:276728 )

• Background Sensitivity: when congenial on CAST/EiJ or WSB/EiJ this Tg causes increased thioflavine S positive (ThioS+) vascular amyloid deposits, indicative of cerebral amyloid angiopathy, but this is not found in congenics on the C57BL/6J or PWK/PhJ host backgrounds

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:276728