Phenotypes Associated with This Genotype

Genotype
MGI:7310209

cn28

• Allelic Composition: Gpbar1^em1Gpt/Gpbar1^em1Gpt; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6JGpt * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:325395 )

• mice fed a high-fat diet and transplanted with fecal microbiota (FMT) from Hif1a^tm1Stom/Hif1a^tm1Stom Tg(Vil1-cre)20Syr mice exhibit no change in food intake, body weight, body fat composition, insulin sensitivity, normal adaptive thermogenesis, and mitochondrial CF activity unlike wild-type mice receiving the FMT, which phenocopy Hif1a^tm1Stom/Hif1a^tm1Stom Tg(Vil1-cre)20Syr mice

• mice fed a high-fat diet and treated with TCA or DCA exhibit no attenuation of body wight gain and body fat content or restored glucose intolerance and insulin resistance or increased adaptive thermogenesis, respiratory exchange ratio, or oxygen consumption unlike control mice