Phenotypes Associated with This Genotype

Genotype
MGI:7260343

• Allelic Composition: Msh5^em1Jzc/Msh5^em1Jzc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent oocytes ( J:241778 )

• no germ cells are seen in the ovaries

abnormal ovarian follicle morphology ( J:241778 )

• no developing follicles are seen in the ovaries at 2 months of age

ovary atrophy ( J:241778 )

• ovary size is dramatically reduced

female infertility ( J:241778 )

• all females are infertile

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:241778 )

• no developing follicles are seen in the ovaries at 2 months of age

ovary atrophy ( J:241778 )

• ovary size is dramatically reduced

cellular

absent oocytes ( J:241778 )

• no germ cells are seen in the ovaries

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ovarian insufficiency 13		DOID:0080870	OMIM:617442	J:241778