Phenotypes Associated with This Genotype

Genotype
MGI:7260274

• Allelic Composition: sar/sar
• Genetic Background: BTBR-sar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:37 )

• plasma sarcosine levels are increased

increased circulating glycine level ( J:37 )

• mean plasma glycine level is increased

increased circulating methionine level ( J:37 )

• plasma methionine level is increased

abnormal urine homeostasis ( J:37 )

• high levels of sarcosine in the urine

methioninuria ( J:37 )

• urinary methionine is increased

abnormal enzyme/coenzyme activity ( J:37 )

• mice show a decrease in sarcosine dehydrogenase activity in mitochondria

renal/urinary system

abnormal urine homeostasis ( J:37 )

• high levels of sarcosine in the urine

methioninuria ( J:37 )

• urinary methionine is increased

growth/size/body

growth/size/body region phenotype ( J:37 )

N • mice exhibit normal weight at 1 and 4 months of age

liver/biliary system

liver/biliary system phenotype ( J:37 )

N • liver tissues do not exhibit abnormalities

nervous system

nervous system phenotype ( J:37 )

N • brain tissues do not exhibit abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sarcosinemia		DOID:0112307	OMIM:268900	J:37