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Phenotypes Associated with This Genotype
Genotype
MGI:6693754
Allelic
Composition		 Ces5aem1Zuk/Ces5aem1Zuk
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ces5aem1Zuk mutation (0 available); any Ces5a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:295177 )
N
• mice exhibit normal testis histology and sperm morphology
decreased sperm progressive motility ( J:295177 )
• with decreased average path velocity and progressive velocity after hyperactivation
abnormal epididymis morphology ( J:295177 )
• dilated lumen, inflammation, and abnormal epithelia
reduced male fertility ( J:295177 )
• male mice sire fewer litters and pups
• however, litter size is normal over 3 month mating period

cellular
decreased sperm progressive motility ( J:295177 )
• with decreased average path velocity and progressive velocity after hyperactivation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/22/2025
MGI 6.24 		The Jackson Laboratory