Phenotypes Associated with This Genotype

Genotype
MGI:6681929

• Allelic Composition: Pmfbp1^em#Jfw/Pmfbp1^em#Jfw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm axoneme morphology ( J:303070 )

♂ • the microtubule doublets of exoneme are slightly affected

abnormal sperm mitochondrial sheath morphology ( J:303070 )

♂ • the mitochondrial sheath is disorganized

absent sperm head ( J:303070 )

♂ • approximately 98% of spermatozoa are acephalic

male infertility ( J:303070 )

♂ • males mate normally with females but fail to produce offspring

♂ • however, females produce offspring when mated with wild-type males, indicating normal female fertility

♂ • however, males show no difference in body weight or testis weight or in seminiferous tubule morphology

cellular

abnormal sperm axoneme morphology ( J:303070 )

♂ • the microtubule doublets of exoneme are slightly affected

abnormal sperm mitochondrial sheath morphology ( J:303070 )

♂ • the mitochondrial sheath is disorganized

absent sperm head ( J:303070 )

♂ • approximately 98% of spermatozoa are acephalic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spermatogenic failure 31		DOID:0111922	OMIM:618112	J:303070