Analysis Tools
mortality/aging
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• mice die 4 to 7 days after birth
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growth/size/body
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• 20% reduction in body weight at birth
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• postnatal growth is severely impeded, despite mice having a milk spot indicating the ability to ingest food and mice fail to gain any weight after birth
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digestive/alimentary system
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• intestines of most mice are filled with dark material that contains high number of red blood cells on P4, indicating bleeding into the lumen
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• reduction in the proliferation rates of intestinal epithelial cells after birth, but not at E18.5, with about 70 and 80% decrease in Ki67+ epithelial cells in both small and large intestines at P2 and P4, respectively
• however, no apoptotic cells are detected in intestinal tissues from P2 to P4
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• severe defect in the development of the lower gastrointestinal tract
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• intestines appear distended as early as P2, but not at E18.5
• essential loss of normal tissue architecture of both small and large intestines by P4
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• reduction of and near complete absence of mucin-producing goblet cells in small and large intestines at P2 and P4, respectively
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• mice show general disorganization of intestinal epithelium within crypts of the large intestine at E18.5
• P2 large intestine exhibits disorganization of surface epithelium
• small intestine shows increased dyslocalization of nuclei within the epithelial layer indicating loss of epithelial cell polarity on P2
• P2 small intestine shows a substantial number of epithelial cells containing very large vacuoles
• abnormal differentiation of intestinal epithelium
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• an increase in shedding of cellular material into the lumen of the large intestine is seen at E18.5
• P2 large intestine exhibits disorganization of surface epithelium and overall loss of crypt structure
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• mice show general disorganization of intestinal epithelium within crypts of the large intestine at E18.5
• P2 large intestine exhibits overall loss of crypt structure
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• decrease in the number of mucin-producing goblet cells in the large intestine at E18.5
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• small intestine shows increased dyslocalization of nuclei within the epithelial layer indicating loss of epithelial cell polarity on P2
• P2 small intestine shows a substantial number of epithelial cells containing very large vacuoles
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• small intestine shows signs of villous atrophy on P2 but not at E18.5
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• relative length of the large intestine is reduced at P2 but not at E18.5
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endocrine/exocrine glands
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• mice show general disorganization of intestinal epithelium within crypts of the large intestine at E18.5
• P2 large intestine exhibits overall loss of crypt structure
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• decrease in the number of mucin-producing goblet cells in the large intestine at E18.5
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cardiovascular system
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• intestines of most mice are filled with dark material that contains high number of red blood cells on P4, indicating bleeding into the lumen
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cellular
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• reduction of and near complete absence of mucin-producing goblet cells in small and large intestines at P2 and P4, respectively
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• decrease in the number of mucin-producing goblet cells in the large intestine at E18.5
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• reduction in the proliferation rates of intestinal epithelial cells after birth, but not at E18.5, with about 70 and 80% decrease in Ki67+ epithelial cells in both small and large intestines at P2 and P4, respectively
• however, no apoptotic cells are detected in intestinal tissues from P2 to P4
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital secretory sodium diarrhea 3 | DOID:0060781 |
OMIM:270420 |
J:261068 | |
