Phenotypes Associated with This Genotype

Genotype
MGI:6437929

• Allelic Composition: Shank3^tm2Cmpl/Shank3⁺
• Genetic Background: B6.129S6-Shank3^tm2Cmpl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:289874 )

• while mice decreased initial coordination on day one of the rotarod, they show improved motor learning retention of day 2 of testing

decreased anxiety-related response ( J:289874 )

• mice show a decrease in the number of marbles buried in the marble-burying task

• however, mice spend similar time in the central, anxiogenic region of the open field as wild-type mice, show similar latency to enter the light chamber in the dark/light test, and spend similar time in the light and dark chambers, and exhibit normal acoustic startle response and prepulse inhibition

increased grooming behavior ( J:289874 )

• mice show increased time spend grooming

impaired coordination ( J:289874 )

♀ • females show decreased latency to fall from the rotarod on day one, however mice show improved motor learning retention on day 2 of testing

decreased vertical activity ( J:289874 )

♀ • females show less rearing while males only show a trend toward less rearing

abnormal social investigation ( J:289874 )

• in the second trial of the 3-chamber test of sociability, mice do not show a preference for the social target over the inanimate object

abnormal response to social novelty ( J:289874 )

• in the third trial of the 3-chamber test of sociability, mice do not show a preference for the social novelty

abnormal social recognition ( J:289874 )

• mice show deficits in social recognition in the social interaction with juvenile test of social memory

nervous system

reduced long-term potentiation ( J:289874 )

• mice exhibit decreased hippocampal long-term potentiation

• however, mGluR-dependent long-term depression is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:289874