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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnpattm1Just mutation (0 available); any Gnpat mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• mice exhibit reduced freezing responses in contextual fear conditioning
• mice show reduced freezing responses in cued fear conditioning
• mice show reduced immobility in the forced swim test
• however, mice show no alteration in the tail suspension test, with mice spending a similar immobile time as wild-type mice
• in the elevated plus maze, mice show increased counts of open arm entries without alternations in the time spent in the open arms indicating slightly reduced levels of anxiety
• in the light/dark box, mice show an increase in exploration distance in the light zone compared to wild-type mice, however, mice do not enter the light zone more often than wild-type mice, indicating slightly reduced levels of anxiety
• however, mice do not show differences in the novelty-suppressed feeding test, indicating no anxiety-related reduced behavior in response to a novel environment
• mice exhibit reduced freezing responses in the contextual and cued fear conditioning
• mice do not at all engage in digging behavior, leaving most marbles in their place, although they interact with the marble by sniffing or trying to bite them
• mice exhibit normal nesting behavior, utilizing the nestlets similarly to wild-type mice, however they show reduced nestlet shredding
• in the 3-chamber sociability test, mice show reduced sociability, with mice spending only slightly more time interacting with the stranger mouse than with the inanimate object
• however, mice show no apparent changes in the response to social novelty

• mice exhibit normal olfaction in the buried food test

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
disease of mental health DOID:150 J:286038

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory