Phenotypes Associated with This Genotype

Genotype
MGI:6377675

cn1

• Allelic Composition: P4hb^tm1.1Geno/P4hb^tm1.1Geno; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:229395 )

• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury

• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect

abnormal platelet dense granule physiology ( J:229395 )

• ATP secretion from dense granules of platelets is about 50% of the normal platelets

decreased susceptibility to induced thrombosis ( J:229395 )

• the time to complete occlusion after FeCl3-induced injury of the carotid artery is doubled

• incorporation of platelets into a thrombus in a FeCL3-induced mesenteric artery thrombosis model is decreased

• however, platelets do not have a defect in fibrin deposition at sites of injury

increased bleeding time ( J:229395 )

• tail bleeding times are approximately doubled

hematopoietic system

hematopoietic system phenotype ( J:229395 )

N • complete blood counts show no abnormalities and platelet counts and size are normal

decreased platelet aggregation ( J:229395 )

• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury

• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect

abnormal platelet dense granule physiology ( J:229395 )

• ATP secretion from dense granules of platelets is about 50% of the normal platelets