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Phenotypes Associated with This Genotype
Genotype
MGI:6360221
Allelic
Composition		 Enpp1asj/Enpp1+
Genetic
Background		 C57BL/6J-Enpp1asj/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp1asj mutation (1 available); any Enpp1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal renal artery morphology ( J:201689 )
• mineralization of the medulary tubules and arcuate and renal arteries is found in heterozygotes, not just homozygotes, when fed a diet rich in phosphorus and low in magnesium

homeostasis/metabolism
decreased circulating phosphate level ( J:201689 )
• heterozygotes have reduced levels of plasma PPi, approximately 60% of normal levels

renal/urinary system
abnormal renal artery morphology ( J:201689 )
• mineralization of the medulary tubules and arcuate and renal arteries is found in heterozygotes, not just homozygotes, when fed a diet rich in phosphorus and low in magnesium

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory