Phenotypes Associated with This Genotype

Genotype
MGI:6331339

• Allelic Composition: Tg(Nphs1-rtTA*3G)8Jhm/0; Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz/0
• Genetic Background: involves: C57BL/6J * CBA/J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

albuminuria ( J:251848 )

• doxycycline-treated mice exhibit albuminuria, as indicated by higher urinary-albumin-to-creatinine ratio level

• mice treated with doxycycline for 14 days and then taken off it for 7 or 17 days, show halted albuminuria development

renal/urinary system

albuminuria ( J:251848 )

• doxycycline-treated mice exhibit albuminuria, as indicated by higher urinary-albumin-to-creatinine ratio level

• mice treated with doxycycline for 14 days and then taken off it for 7 or 17 days, show halted albuminuria development

abnormal podocyte morphology ( J:251848 )

• marker analysis indicated severe podocyte dedifferentiation in doxycycline-treated mice

podocyte foot process effacement ( J:251848 )

• doxycycline-treated mice exhibit increased foot-process effacement

decreased podocyte number ( J:251848 )

• podocyte number is reduced in doxycycline-treated mice

podocyte vacuoles ( J:251848 )

• increase in number of multivesicular bodies, amphisomes, and autophagosomes in podocytes of doxycycline-treated mice

• the ratio of autophagic vacuoles to autolysosomes is increased in podocytes of doxycycline-treated mice, indicating an increase in autophagic vacuole content

glomerulosclerosis ( J:251848 )

• doxycycline-treated mice show an increase in global and segmental glomerulosclerosis

• by 3 weeks after doxycycline induction, mice develop severe global and segmental sclerosis

abnormal podocyte physiology ( J:251848 )

• podocytes from doxycycline-treated mice show increased inflammatory cell death (pyroptosis)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
kidney disease		DOID:557		J:251848