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Phenotypes Associated with This Genotype
Genotype
MGI:6317327
Allelic
Composition
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (153 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 14 days, with mice starting to die around 10 days and most die by 20 days of age

renal/urinary system
• increase in cyst epithelial cell proliferation
• mice develop an early-onset and rapidly fatal form of polycystic kidney disease

cellular
• increase in cyst epithelial cell proliferation

homeostasis/metabolism

growth/size/body
• mice develop an early-onset and rapidly fatal form of polycystic kidney disease

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:244067


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory