Phenotypes Associated with This Genotype

Genotype
MGI:6305084

• Allelic Composition: Tg(MECP2)1Hzo/0
• Genetic Background: FVB-Tg(MECP2)1Hzo/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal visual evoked potential ( J:253720 )

• V1 neurons show age-dependent change in firing rate, with higher evoked responses at 8 weeks but lower at 14 weeks and lower firing rates to low and high spatial frequencies in 14 week old V1 neurons

abnormal visual acuity ( J:253720 )

• primary visual cortex (V1) neurons show a preference for higher spatial frequencies at 8 and 14 weeks of age indicating higher visual acuity

• in a two-alternative forced choice visual detection task, mice exhibit higher behavioral performance in spatial frequency detection

abnormal visual contrast sensitivity ( J:253720 )

• V1 neurons show age-dependent (at 8 weeks but not 14 weeks of age) change in contrast sensitivity, indicating higher contrast sensitivity

• behavioral performance in visual detection of stimuli that varies in contrast shows improved performance in detecting low contrasts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic X-linked intellectual disability Lubs type		DOID:0060799	OMIM:300260	J:253720