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Phenotypes Associated with This Genotype
Genotype
MGI:6285778
Allelic
Composition		 RelM2Btlr/RelM2Btlr
Genetic
Background		 C57BL/6J-RelM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelM2Btlr mutation (0 available); any Rel mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:272778 )
• expression of CD44 was reduced on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272778 )
• expression of CD44 was reduced on CD4+ T cells
decreased B-1 B cell number ( J:272778 )
• reduced frequencies of B1 cells in the peripheral blood
decreased alpha-beta T cell number ( J:272778 )
• reduced frequencies of CD44+ T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of CD44+ CD4 T cells in the peripheral blood
decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:272778 )
• expression of CD44 was reduced on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272778 )
• expression of CD44 was reduced on CD4+ T cells
decreased B-1 B cell number ( J:272778 )
• reduced frequencies of B1 cells in the peripheral blood
decreased alpha-beta T cell number ( J:272778 )
• reduced frequencies of CD44+ T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of CD44+ CD4 T cells in the peripheral blood
decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )
• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/26/2026
MGI 6.24 		The Jackson Laboratory