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Phenotypes Associated with This Genotype
Genotype
MGI:6278980
Allelic
Composition
Tg(TBK1)#Andm/0
Genetic
Background
B6J.Cg-Tg(TBK1)#Andm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice exhibit progressive retinal ganglion cell loss with age, with a 9% decrease in ganglion cells at 3 months of age and 13% loss at 18 months of age
• however, mice have normal intraocular pressure at 5 weeks, 3 months, 7 months, 12 months, and 18 months of age

nervous system
• mice exhibit progressive retinal ganglion cell loss with age, with a 9% decrease in ganglion cells at 3 months of age and 13% loss at 18 months of age
• however, mice have normal intraocular pressure at 5 weeks, 3 months, 7 months, 12 months, and 18 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
low tension glaucoma DOID:13544 J:241433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory