About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6276135
Allelic
Composition
Tg(Myh6-Camk2d_ic)#Jhb/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after AV node ablation, hearts show higher intrinsic ventricular heart rates
• application of 2 consecutive premature beats via programmed electrical stimulation induces monomorphic and polymorphic ventricular tachyarrhythmias
• isoproterenol infusion induces monomorphic ventricular tachyarrhythmias in mutants while it only increases the heart rate with no arrhythmias in wild-type mice
• the effective refractory period is decreased in hearts
• corrected QT interval is prolonged indicating prolonged repolarization
• monocytes show slower fast sodium current inactivation, enhanced late sodium current, increased intracellular sodium concentration, enhanced accumulation of intermediate sodium current inactivation, slower recovery from inactivation and a shift of steady-state inactivation of sodium channels to more negative membrane potential

nervous system
• at lower pacing frequencies, monophasic action potential duration is prolonged in hearts
• however, at high pacing frequencies, monophasic action potential duration is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congestive heart failure DOID:6000 J:117345


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/24/2023
MGI 6.22
The Jackson Laboratory