Phenotypes Associated with This Genotype

Genotype
MGI:6276135

• Allelic Composition: Tg(Myh6-Camk2d_ic)#Jhb/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart rate ( J:117345 )

• after AV node ablation, hearts show higher intrinsic ventricular heart rates

ventricular tachycardia ( J:117345 )

• application of 2 consecutive premature beats via programmed electrical stimulation induces monomorphic and polymorphic ventricular tachyarrhythmias

• isoproterenol infusion induces monomorphic ventricular tachyarrhythmias in mutants while it only increases the heart rate with no arrhythmias in wild-type mice

abnormal impulse conducting system conduction ( J:117345 )

• the effective refractory period is decreased in hearts

shortened PR interval ( J:117345 )

prolonged QRS complex duration ( J:117345 )

prolonged QT interval ( J:117345 )

• corrected QT interval is prolonged indicating prolonged repolarization

abnormal myocardial fiber sodium currents ( J:117345 )

• monocytes show slower fast sodium current inactivation, enhanced late sodium current, increased intracellular sodium concentration, enhanced accumulation of intermediate sodium current inactivation, slower recovery from inactivation and a shift of steady-state inactivation of sodium channels to more negative membrane potential

congestive heart failure ( J:117345 )

nervous system

abnormal action potential ( J:117345 )

• at lower pacing frequencies, monophasic action potential duration is prolonged in hearts

• however, at high pacing frequencies, monophasic action potential duration is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:117345