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Phenotypes Associated with This Genotype
Genotype
MGI:6276042
Allelic
Composition
Tg(Myh6-Camk2d_ic)MJhb/0
Genetic
Background
either: (involves: Black Swiss) or (involves: C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice show enlargement of hearts by 8-10 weeks of age
• marker analysis indicates overexpression of genes associated with cardiac hypertrophy

mortality/aging
• 50% of mice die prematurely, most by 16 weeks of age

cardiovascular system
• 12 week old mice show a 26% increase in lung/body weight ratio, indicating pulmonary congestion
• mice show enlargement of hearts by 8-10 weeks of age
• marker analysis indicates overexpression of genes associated with cardiac hypertrophy
• mild fibrosis
• mice exhibit ventricular dilation and cardiac dysfunction
• fractional shortening is decreased by 50-60% at 8 weeks of age
• M-mode echocardiography indicates a 50% increase in left ventricular mass to body weight ratio by 8 weeks of age
• left ventricular end diastolic diameter is increased by 35-45%, left ventricular posterior wall thickness is decreased by 26-29% and fractional shortening is decreased by 50-60% at 8 weeks of age
• ventricular myocytes isolated from 12 week old mice and stimulated at 0.5 Hz show decreased contractile function, and slightly increased average half-relaxation time
• marker analysis indicates overexpression of genes associated with heart failure

homeostasis/metabolism
• mice exhibit atrial thrombi
• severe edema

muscle
• mice exhibit ventricular dilation and cardiac dysfunction
• fractional shortening is decreased by 50-60% at 8 weeks of age

respiratory system
• 12 week old mice show a 26% increase in lung/body weight ratio, indicating pulmonary congestion


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory