Phenotypes Associated with This Genotype

Genotype
MGI:6275172

• Allelic Composition: Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:239660 )

♂ • rare areas in prostate show outlier levels of androgen receptor expression and rare cells show cytologic atypia with enlarged nuclei in mice older than 12 months

♂ • however, mice show minimal alterations in prostate grandular architecture and histology, no differences in proliferation or androgen receptor expression

reproductive system

abnormal prostate gland morphology ( J:239660 )

♂ • rare areas in prostate show outlier levels of androgen receptor expression and rare cells show cytologic atypia with enlarged nuclei in mice older than 12 months

♂ • however, mice show minimal alterations in prostate grandular architecture and histology, no differences in proliferation or androgen receptor expression