Phenotypes Associated with This Genotype

Genotype
MGI:6273993

• Allelic Composition: Tg(RP11-578M14)5Mkru/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:256501 )

• fat mass is increased in 20 week old mice

• however, lean mass is normal

increased body weight ( J:201055 )

• males and females are 4.1-7.5% and 6-14.3% heavier than wild-type mice, respectively, from 7 weeks of age

homeostasis/metabolism

impaired adaptive thermogenesis ( J:256501 )

• mice exhibit lower core body temperature during acute cold stress at 20 weeks of age

• however, mice exhibit normal energy expenditure and normal food intake and activity levels

abnormal blood homeostasis ( J:256501 )

• mice exhibit elevated C-peptide levels at 20 weeks of age

increased fasting circulating glucose level ( J:256501 )

• males and females exhibit elevated fasting blood glucose at 20 weeks of age

• fasting blood glucose levels are elevated only in females at 5 weeks of age

abnormal circulating hormone level ( J:256501 )

♂ • fasting plasma peptide YY (PYY) and amylin levels are elevated in males prior to obesity

♂ • however, PYY levels are similar to wild-type at 20 weeks of age, while amylin levels are still elevated at 20 weeks of age

♂ • fasting plasma resistin levels are elevated only in males at 20 weeks of age

♂ • however, fasting plasma glucagon and gastric inhibitory polypeptide levels are normal

decreased circulating ghrelin level ( J:256501 )

♂ • fasting plasma ghrelin levels are lower in males prior to obesity

♂ • however, ghrelin levels are similar to wild-type at 20 weeks of age

decreased circulating follicle stimulating hormone level ( J:256501 )

♂ • follicle stimulating hormone levels are lower in obese males at 20 weeks of age

decreased circulating luteinizing hormone level ( J:256501 )

♂ • luteinizing hormone levels are lower in obese males at 20 weeks of age

increased circulating insulin level ( J:256501 )

• mice exhibit elevated fasting plasma insulin levels at 5 and 20 weeks of age

increased circulating leptin level ( J:256501 )

• mice exhibit higher fasting plasma leptin levels at 20 weeks of age

decreased circulating thyroid-stimulating hormone level ( J:256501 )

♂ • thyroid stimulating hormone levels are lower in obese males at 20 weeks of age

decreased circulating free fatty acids level ( J:256501 )

♀ • non-esterified fatty acids are lower in females at 5 weeks of age

♀ • however, levels of non-esterified fatty acids are similar to wild-type levels at 20 weeks of age

increased circulating phospholipid level ( J:256501 )

• females exhibit elevated phospholipid levels at 5 weeks of age and both males and females exhibit higher phospholipid levels at 20 weeks of age

impaired glucose tolerance ( J:256501 )

• mice exhibit glucose intolerance at 20 weeks of age

• however, insulin sensitivity is similar to wild-type mice at 20 weeks of age

decreased growth hormone level ( J:256501 )

♂ • growth hormone levels are lower in obese males at 20 weeks of age

decreased prolactin level ( J:256501 )

♂ • prolactin levels are lower in obese males at 20 weeks of age

increased cholesterol level ( J:256501 )

• mice exhibit higher cholesterol levels at 20 weeks of age

increased triglyceride level ( J:256501 )

• mice exhibit higher triglyceride levels at 20 weeks of age

adipose tissue

increased brown adipose tissue amount ( J:256501 )

• mice exhibit greater brown adipose tissue percentage at 20 weeks of age, but not at 5 weeks

increased white adipose tissue amount ( J:201055 , J:256501 )

• white adipose tissue percent is increased (J:201055)

• mice exhibit greater gonadal white adipose tissue and inguinal white adipose tissue percentage at 20 weeks of age, but not at 5 weeks (J:256501)

increased body fat mass ( J:256501 )

• fat mass is increased in 20 week old mice

• however, lean mass is normal

increased white fat cell size ( J:256501 )

• adipocytes are 50% larger in gonadal white adipose tissue and 27% larger in inguinal white adipose tissue depots

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome		DOID:0060611	OMIM:PS605552	J:256501
obesity		DOID:9970	OMIM:601665	J:256501